منابع مشابه
PLATELETS AND VASCULAR OCCLUSION Thromboxane A2 and prostaglandin endoperoxide receptors in platelets and vascular smooth muscle
9,1 1-Dimethylmethano11, 12-methano16-(3-iodo-4-hydroxyphenyl)13, 14-dihydro13-aza-15a/3-w-tetranor-TXA2 (I-PTA-OH), a recently synthesized thromboxane (TX) A2/prostaglandin (PG) H2 receptor antagonist, was shown to be a competitive antagonist of human platelet aggregation induced by the stable endoperoxide analog U46619. This antagonism was due to competitive blockade of the platelet TXA2/PGH2...
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The role of oxidized high-density lipoprotein (oxHDL) and the protective effects of adiponectin in terms of vascular calcification is not well established. This study was conducted to investigate the effects of oxHDL with regards to inflammation and vascular calcification and to determine the protective role of adiponectin in attenuating the detrimental effects of oxHDL. Cell viability, mineral...
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• This brief review of the rapidly developing research on vascular smooth muscle presents the state of the art as I see it from within my own frame of reference. For a more objective, detailed insight into the workings of vascular smooth muscle, several substantial reviews and compendiums may be read (1-7). The mechanical events responsible for the contraction of vascular smooth muscle are asso...
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Recent observations in our laboratory suggest that angiotensin II (Ang II) is a bifunctional vascular smooth muscle cell (VSMC) growth modulator capable ofinducing hypertrophy or inhibiting mitogen-stimulated DNA synthesis. Because transforming growth factor-,61 (TGFfIi) has similar bifunctional effects onVSMC growth, we hypothesized that autocrine production of TGFfti may mediate the growth mo...
متن کاملVascular Smooth Muscle
In 1653, the English physician William Harvey published the first comprehensive study of blood vessels, De Motu Cordis.1 This classic treatise delineated the directions of blood flow, differences between veins and arteries, functions of venous ''valves,' and anatomy of the systemic and pulmonary circulations. By the 19th century, the major layers constituting blood vessels were identified and o...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1979
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)66847-2